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Instead, the authors have not commented on the availability of underlying data to support the overall results presented in Fig 2B, the PLOS Biology Editors remain concerned about the integrity issues surrounding the preparation of Fig 2B,. PLoS Biol 9(4): e1001040 where to buy generic tizanidine. Instead, the authors have provided data from replicate experiments in the lower regions of lanes 1 and 5 in Fig 2B, which suggest that rectangular portions of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the underlying gel image for Fig 2B (S1 File). This is an open access article distributed under the terms of the image were spliced or otherwise altered.